2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N4253
    Kudinoside D 173792-61-5 99.80%
    Kudinoside D is a main natural component of triterpenoid saponin derived from Ilex kudingcha. Kudinoside D suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes.
    Kudinoside D
  • HY-N4298
    Epitheaflagallin 3-O-gallate 102067-92-5 98.48%
    Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts.
    Epitheaflagallin 3-O-gallate
  • HY-N5023
    Veraguensin 19950-55-1 99.89%
    Veraguensin is a lignan compound derived from Magnolia sp.. Veraguensin can inhibit bone resorption
    Veraguensin
  • HY-N5097
    13-Oxo-9E,11E-octadecadienoic acid 29623-29-8
    13-Oxo-9E,11E-octadecadienoic acid, an isomer of 9-oxo-ODA, is a potent PPARα activator derived from tomato juice. 13-Oxo-9E,11E-octadecadienoic acid decreases plasma and hepatic triglyceride in obese diabetic mice.
    13-Oxo-9E,11E-octadecadienoic acid
  • HY-N5099
    N-Vanillyldecanamide 31078-36-1 99.86%
    N-Vanillyldecanamide, a capsaicinoid isolated from the fruits of Capsicum annuum, significantly reduced the radical length of Lactuca sativa seedling in a dose-dependent manner.
    N-Vanillyldecanamide
  • HY-N6264
    26-Deoxyactein 264624-38-6 99.76%
    26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels.
    26-Deoxyactein
  • HY-N6580
    Ginsenoside Rg4 126223-28-7 99.94%
    Ginsenoside Rg4 is an orally active protopanaxatriol type ginsenoside. Ginsenoside Rg4 can activate PI3K, AKT and GSK-3β signaling. Ginsenoside Rg4 can inhibit ROS and inflammatory cytokine levels. Ginsenoside Rg4 can be used for the researches of inflammation, infection and metabolic disease, such as sepsis and lung inflammation.
    Ginsenoside Rg4
  • HY-N6584
    Saikogenin A 5092-09-1 99.99%
    Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.
    Saikogenin A
  • HY-N6650
    Isotanshinone IIA 20958-15-0 98.0%
    Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM.
    Isotanshinone IIA
  • HY-N6853
    Mogroside I E1 88901-39-7 98.46%
    Mogroside I E1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.
    Mogroside I E1
  • HY-N6854
    Mogroside I A1 88901-46-6 99.77%
    Mogroside I A1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.
    Mogroside I A1
  • HY-N6875
    Oleuropeinic acid 96382-90-0
    oleuropeinic acid is present initially in olive tissues or formed by the thermal treatment, possibly by the oxidation of oleuropein. Oleuropeinic acid is an antioxidant-soluble fiber.
    Oleuropeinic acid
  • HY-N6897
    Podecdysone B 22612-27-7 98.42%
    Podecdysone B is a phytoecdysone isolated from Cyanotis arachnoidea.
    Podecdysone B
  • HY-N6899
    Crocetine dimethyl ester 5892-54-6 98.32%
    Crocetine dimethyl ester (Dimethylcrocetin) is found in the stigmas of saffron (Crocus sativus L.), and has antioxidant activity.
    Crocetine dimethyl ester
  • HY-N6901
    Luteolin 7-sulfate 56857-57-9
    Luteolin 7-sulfate is isolated from Phyllospadix iwatensis Makino, a marine plant. Luteolin 7-sulfate attenuates TYR gene expression through the intervention of a cAMP-responsive element binding protein (CREB)- and microphthalmia-associated transcription factor (MITF)-mediated signaling pathway, leading to the decreased melanin synthesis.
    Luteolin 7-sulfate
  • HY-N6912
    Regelidine 114542-54-0 98.08%
    Regelidine is a natural product isolated from the stems of Tripterygium regelii.
    Regelidine
  • HY-N6913
    3α-Hydroxymogrol 1343402-73-2 99.88%
    3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent AMPK activator, and enhances AMPK phosphorylation.
    3α-Hydroxymogrol
  • HY-N6920
    11-Oxomogroside IIIE 2096516-68-4 99.69%
    11-Oxomogroside IIIE is a cucurbitane triterpene glycoside isolated from Lo Han Kuo (Siraitia grosvenori).
    11-Oxomogroside IIIE
  • HY-N6922
    Danshenxinkun B 65907-76-8 99.89%
    Danshenxinkun B is an antioxidative component of tanshen (Salvia miltiorhiza Bung) .
    Danshenxinkun B
  • HY-N6923
    N-(3-Methoxybenzyl)oleamide 883715-21-7 99.24%
    N-(3-Methoxybenzyl)oleamide (MAC 18:1) is an individual macamide. N-(3-Methoxybenzyl)oleamide can be isolated from Lepidium meyenii (maca).
    N-(3-Methoxybenzyl)oleamide
Cat. No. Product Name / Synonyms Application Reactivity